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Son Lux first experimented with writing for dance choreography. It was during that time that he developed an ear for grand operatic compositions, an element that still has its place in his recent solo works. Using his voice and almost microscopical samples he builds hip-hop inspired beats and orchestrated electronical arrangements.

While his debut album took four years to write and record, he finished his sophomore album in just 28 days. Although this was a major challenge, it seems to have been a pivotal experience for Lott as a songwriter, as he has released another full length album and a collaboration EP with Lorde since. Later she would go to the Berklee College of Music and release an EP with a couple of fellow students before dropping out.

Until he was given tapes to listen to by his older sister. He soon wanted more, and via punk, rap, and hardcore in high school, to psych, folk and Indian classical music as he grew up; Steve was always on the lookout to broaden his horizon. The same devotion drove him to become an increasingly proficient guitar player over the course of his 15 years being a career musician. Their dissonant art rock is widely renowned for their unparalleled implementation of dark electronic elements and paranoid drone-noise which, especially in a live setting, completely washes over you and fills the room.

Together with long time friend Radwan Ghazi Moumneh of Jerusalem In My Heart they rented a studio for seven days for a collaborative session, resulting in a set of vibe-laden songs full of heavy analog synths, Arabic influences and emotive electronics. The recordings were laid to rest for a full year, before two shows in and a final rework of the album in the summer of kickstarted the project back to life. Their live show, which varies from soothing and slightly disturbing to enthrallingly vigorous, is not about playing the songs note for note but more about capturing the excitement those initial sessions.

This young band from the north of the Netherlands creates atmospheric dreampop with electronic drumbeats, airy guitars and vocals, and occasional explosions of sounds. With hypnotic repetition, subtle layers of melody, tasteful interludes of ambient noise and field recordings, Swedish trio Tape blend acoustic instrumentation with electronics to craft a beautiful, film-like listening experience.

In most of their fragile compositions, drums are absent but seldom missed. The tracks are naturally light and float upwards. It takes a lot of skill and confidence for a group of artists to play so few notes, letting the music organically breathe and evolve. Formed in after a bet, this formation exists completely of family and friends. The Vaselines Formed in , The Vaselines released just two singles and one album before they split in , in the same week as they released their album.

They shortly reunited in to open for Nirvana as a one-time thing. With elements of folk and country subtly present, The Walking Who are a psychedelic rock band best enjoyed with your eyes closed. Often drenched in reverb, the guitars are equally present as they are unobtrusive, even sparse at times. The Walking Who ride a jam-like wave, seemingly unaware of the world around them as they float away nodding their heads to the muffled drum kicks.

Using modular synthesizers, contact microphones and junkyard percussion, they create trembling rhythms and extended tones that transcend both the artist and audience beyond their limits. Thug Entrancer Armed with a small arsenal of vintage analog drum machines and synths, experimental musician Ryan McRyhew left Denver for South Chicago in His lengthy compositions are often quite dark, with ambient sounds layered over hypnotic, endless beat patterns.

Their minimalistic approach to songwriting and heavy use of electronic sounds makes it sound quite robotic, even danceable. Their self-titled debut was produced by John McEntire of labelmates Tortoise. Together with contemporaries such as Tortoise and. Hakan started the project in and recorded his first album in the city where he was born and raised, Istanbul, in His folky instrumental songs are very atmospheric, creating an intimate and melancholic atmosphere.

Their debut album BiRd-BrAiNs was completely self-recorded, produced using a hand-held voice recorder and released on recycled cassette tapes and as a pay-what-you-want digital download. The surprisingly soulful mix of sounds gradually found its way to the hearts of music lovers around the world. With guitar, bass, drums and tenor sax they occupy a vibrant place somewhere between rock, improvised jazz, noise and Ethiogroove.

Front and centre is charismatic vocalist Asnake Guebreyes from Addis Abeba, chanting Ethiopian soul melodies that transcends the highly energetic music to unheard places. They deliberately cross all traditional musical borders, creating something new and unique while at the same time staying true to the origins of the genres they magically melt into one. The slightly lo-fi recorded songs of Viet Cong can at times be noisy and aggressive, but certainly show a sharp ear for atmospheric pop melodies.

By inviting additional band members from different projects they were previously involved with, they have made Viet Cong into a full-fledged band with a diverse though distinct sound ranging from jangly pop and psychedelic folk to bouncy garage rock. White Lung In early , a few young creatives of Vancouver, Canada were deeply discontent with the lack of venues in their area with an interest in noise and experimental music.

White Lung, an unforgiving punk band fronted by female vocalist Mish Way, was one of the bands that managed to acquire widespread acclaim as one of the standout bands emerging from this scene. They play their loud, vicious melodies and piercing hooks with undeniable vigor.

Mostly consisting of his unconventional drumming and her powerful voice, they make experimental pop, with almost spiritual qualities. Their post-noise infused rock has the amps permanently locked in overdrive with loads of sustain, as the reverberated vocals and pounding drums propel the songs forward. Mouth to Mouth curated by M. Artists are chosen based on their ability to resuscitate, set fire to the air, or to mesmerize. All of the performers chosen I find personally to be compelling in this regard.

The goal: joy! After ten years it was time to return to the life of a performance artists and she joined the Coney Island Circus Sideshow and Kamikaze Freak Show as an accordion playing hermaphrodite. She never thought of becoming a recording artist until her songs found their way to David Tibet Current 93 , who encouraged her to record an album.

His sound has evolved increasingly electronic and drone-like, completely encapsulating the listener in a throat grabbing alternate reality. Steering clear of comfort, he finds satisfaction in making music that feels dangerous. Via different bands and projects involving industrial dance and alt-country, she finally ended up releasing her solo debut in Father Murphy Father Murphy are a mystifying duo hailing from northern Italy.

Over the last years they have released three albums and a near overkill of EPs and limited edition releases, on which their sound has evolved from psychedelic pop to a much more woozy and darker tone. Frantic chants mixed with whispers cover ill-defined religious themes such as enlightenment through self-injury.

Various published articles, novels and a total of four albums, two of which as her moniker Rockettothesky, have 52 Le Guess Who? Leafcutter John As a programmer of his own music software and builder of his own electronic equipment, John Burton a. Leafcutter John knows exactly how to get the sounds he wants. He uses samples, even live samples, of everyday objects and processes them to create mesmerizing electronic compositions.

In his more recent works, his roots as a folk musician have found a more prominent place, giving way to the guitar and piano layered with ambient sound samples. She delivers a contemporary cello performance where noise and jazz go hand in hand with composition and improvisation. With electronic drones, throbbing rhythms and electronic melodies this duo from was far ahead of its time. They allegedly used all of their hands, knees, elbows and feet to tinker with the 86 controls needed to record their debut.

After releasing a follow up a year later, they mysteriously vanished from the face of the earth. Then suddenly, decades later in , they resurfaced into a world more accustomed to electronic experimentation and finally got the critical acclaim they deserved. Prurient is the one-man noise project of Dominick Fernow also known as Vatican Shadow. As one of the most influential names in the field of noise, his puristic anti-technology approach is unusual and outstanding.

With microphone, recorder and amplifier being the only electrical components in his setup, he creates all his sounds by using his vocals and banging objects together. Scrap metal and found objects are recycled into installations and musical instruments. Sir Richard Bishop Guitar virtuoso Sir Richard Bishop has released almost albums and tapes since with his three-piece outfit Sun City Girls, and somehow still finds the time and inspiration to pursue a solo career as well.

Drawing from a worldwide palette of sounds and sources, he pays homage to the great folk musicians of the middle east, Africa, India and Asia. His skill, speed and natural urge to improvise is dazzling to say the least and leaves you wondering how one man can create such rich compositions using just an acoustic guitar.

The idea was inspired by the Dada movement, which during the first World War aimed to make sense of the disordered world through sounds and simultaneous poetry. In a similar way Savages and Bo Ningen have created a thematic album consisting of one minute track loosely based around five chapters.

The bands perform simultaneously in the same room, feeding off each other and creating a dynamic in which the individual musician is inferior to the composition as a whole. Swans With the fittingly titled Swans, band leader Michael Gira combines majestic beauty with a fearsome temper. With a sluggish slave boat rhythm he chants his audiences into bedeviled oblivion. After 15 years of spreading their bleak and brutally violent mixture of industrial post-punk and experimental noise rock, they went on an indefinite hiatus in and reformed in Around the same time as he was traveling all over Europe to perform with the Abbey Boys Choir, he learned to play the classical Spanish guitar.

In his teens he formed a psych-rock band with reasonable success, but when they broke up after eight years Herrero went back to his roots of the Spanish guitar. Their sound ranges from guitar based post-punk to electronically sequenced compositions.

Xiu Xiu Listing a diverse array of influences including David Lynch films, Asian percussion music and the books of Elfriede Jelinek, Xiu Xiu have released over 50 artistic works. Their music is very diverse and polarizing, ranging from indie rock masterpieces and electronically oriented dancefloor fillers to brittle folk gems. Giorgos Xylouris and Jim White join forces as Xylouris White, in which they mix traditional Cretan music with rock patterns.

Xylouris is a Greek lute player, while White plays shows all over the world as the drummer of Australian instrumental rock band Dirty Three. The unique combination has spawned a cultural melting pot unlike anything else with traditional Cretan melodies driven by relentless drum patterns. The project will cover the entire spectrum of drone during 24 non-stop hours of live performances and installations.

This program will be streamed live on the website and app of Concertzender. Sound as Installation. Sound without Time. To honor sound in a space that enhances it and long form time schedule that allows it to expand. Seems like something we, Lovers of Sound, should do to honor the making of sound. A 24 Hour Drone is to be an all encompassing experience.

With his endless strive for perfection and technical expertise on the sitar, he. Dirk Serries Belgian-based artist Dirk Serries has the ability to seemingly slow down time until a phase of transcendence sets in. Serries deliberately avoids using any hooks in his music, but instead returns ambient music to its origins by creating subtle, delicate soundscapes. Armed only with his Gibson Les Paul custom guitar and a modest collection of pedals, Serries challenges us all to rethink the meanings of sound and silence.

Exploring the visceral borderlands of noise and music, Emptyset is on an everlasting quest to find the sweet spot where the two overlap. Their debut album was primarily 62 Le Guess Who? Emptyset is known for experimenting with other art forms to create a symbiotic relationship between different elements, like process based image making and electromagnetism. With over 15 years of experience as a drummer in various bands and genres, including an extensive two year tour with psychedelic wonder kid Jacco Gardner, Jos van Tol decided to make an introvert solo album.

Using computer programming techniques and dissecting the physical hardware of the computer, he aims to research the possibilities of learning to play the computer as a complete instrument, like you would learn to play the guitar.

Julianna Barwick gracefully creates delicate, mostly wordless soundscapes with the power of her angelic voice alone. She begins most tracks with a single vocal expression, and then uses a loop station and sometimes a piano or percussion to build layer upon layer, creating a rich, dreamy piece of ambient folk. You can almost see the dew settle on the bushes and windows as her airy sounds float away on a subtle cold morning breeze.

House of Cosy Cushions Last hour live performance Founded by Dutch-English musician and visual artist Richard Bolhuis, House of Cosy Cushions is an ever-changing music collective with a set of core players and additional musicians drifting in and out. Their mostly instrumental tracks are an exploration of the dark and ominous, while also leaving space for melancholic beauty. Together with the Fox String Quartet, led by cellist Maarten Vos, the musicians partially reject these structures and constantly challenge each other to add nuance and dynamics to the play based on improvisation.

Hyde Park provides unique visuals to the concert. The sho is a traditional Japanese mouth organ, mostly used in court music called gagaku. The instrument consists of 17 bamboo pipes, and has a distinct sound that vaguely resembles a church organ. Especially for her performance during the Hour Dronefest, Sato prepared a composition in which tradition and innovation meet. Raime London-based duo Joe Andrews and Tom Halstead take notes from genres such as industrial, techno and dubstep to create their own brand of deep, dark ambient.

With bleak, metallic sounds, brutal percussion and spacious soundscapes they paint a mental image of a dystopian, post-apocalyptic future in which everything is desolate and pitch dark. His solo work is a lot more electronic and mellow. His compositions usually build up slowly and sound stretched out, with one tone or melody constantly meandering through the entire length of tracks. Drawing comparisons to a scientist, Hauschildt was always the quiet one tinkering with electronics while the others put on a show.

Early on in his career Tim Hecker debuted as techno producer Jetone, before losing the connection he once felt to that genre. Delving into abstract sound collages proved to be a much more rewarding experience and within a year he debuted once more, this time with an ambient release under his own name. Hecker, a digital acoustics and software student, uses computer generated noise and found sounds to create elaborate soundscapes that become pulverizing live.

William Basinski Although William Basinski is a classically trained clarinetist and saxophonist, he specializes in using this background in combination with tape loops and drones. By playing short loops back against themselves, he experiments with feedback loops and in the process developed his meditative and desolate sound.

Instead of throwing them away, Basinski liked the dystopian feeling of slowly crumbling tape and was able to put together an album with it before they became unsalvageable. These recordings became the four-part masterpiece The Disintegration Loops. A diverse collection of musicians coming from Portugal, Venezuela, Brazil, U. The result is unprecedented in its liberating exploration of trippy, tropical psychedelica. Not only have they released four full-length albums in just two years, they have recently returned from touring with enough new material to release two more LPs in the next months.

The Growlers With one of the most recognizable sounds around, Californian band The Growlers are one in a million. Their mix of surf rock with country, psychedelica and lo-fi garage pop could be the perfect soundtrack to any hazy surf compilation or Mexican spaghetti western movie. Their sound is characterized by muffled vocals, shrouded in layers of echoing guitar riffs and unforgiving, repetitive drumming. Hampson once claimed he knew only four chords at the time of forming the band.

Loop split in , having released three studio albums before reforming in , with the original line-up of their third album. Growing up in Mali in an era plagued by civil war, having lost many friends and relatives, this band was formed when a group of somethings decided it was time to forget about weapons and spread awareness through music.

Initially they only played traditional Tuareg music, but slowly began incorporating western styles into their desert blues, inspired by the likes of Hendrix and Pink Floyd. Benjamin Booker is doing everything right. He has incorporated his Southern heritage of soul and gospel into his raw blend of blues inspired garage rock.

Chuckamuck With gloriously sloppy live shows and irrepressible energy, Chuckamuck have completely reinvigorated the Berlin indie scene. The unapologetic young group of Berliners sing poppy garage rock songs about girls, hitchhiking to Amsterdam, roller coasters, pinball, and swimming pools - all in German. They implement surfy licks and new wave guitar sounds with the vigor of garage rock, into something that feels undeniably fresh and current. Simply put: they rock hard as hell.

The Coathangers All-girl band The Coathangers started as kind of a party joke. They played a one-off house show when they could barely play their instruments, somehow completely nailed it, and were immediately asked to open for The Hiss based purely on the strength of their performance.

Travelling alongside his gospel singing parents as a child, Curtis Harding learned an important lesson: beautiful melodies mean nothing if they lack honesty. At the moment though, Curtis is focussing on his solo career, with his debut album released on Burger Records. Danny Kroha, founding member of legendary Detroit punk outfit The Gories, has never been shy of new projects and bands after The Gories disbanded.

While also performing solo, drummer Richie Wohlfeil stumbled across Kroha in a stripped-down folky blues phase and suggested a jam session with bassist Colleen Burke. Deers is an all-girl lo-fi garage pop band from Madrid, Spain. The warm, sunny climate of their hometown shines through in the form of surfy guitar licks and sweet lollypop melodies. With their carefree enthusiasm they are effortlessly charming, but also prove they know how to write infectious garage pop songs.

The Garden Not many bands invent a genre and name it too. Twin brothers Wyatt and Fletcher Shears, a bass and drums duo from California, have done so. Their raw, seducing mix of post-punk, lo-fi, synthpop, neo-punk and hip hop elements is called Vada Vada and is as unstable as it is intriguing. Which is probably the last thing on their mind.

The Intelligence Creative mastermind and founder of The Intelligence Lars Finberg began making four-track recordings in his garage in. A prolific slur of singles, splits, EPs, albums and compilation appearances later, their sound or rather: recording preference has moved away from the lofi DIY aesthetic of their earliest releases, without compromising in intensity.

The Intelligence cleverly combines post punk with pop hooks, which results in an irresistible array of songs that capture the youthful energy of garage with the intellectual satisfaction of post-punk cleverness. Having left Uruguay to find work in New York, Juan Wauters did find work in a factory, but found no satisfaction in the dull working life.

As a distraction he turned to music, and within two years after immigrating he founded garage rock band The Beets. This folky garage pop gem with psychedelic undertones is a refreshingly lighthearted joy to listen to, and somehow a perfect fit for all four seasons. Liquor Store The all-American goofballs of Liquor Store could not have chosen a more fitting bandname. He probably made out with your sister backstage before the show. The Miseries The Miseries is the newest project of Dutch singer-songwriter Tim Knol, who is best known for his more delicate pop songs.

With The Miseries he trades in his sensitive side for garage punk rock songs about girls and parties. Not surprisingly, the idea for the band came when they were completely drunk, and they decided it was about time to do something with their love of punk.

They cranked up their amps and laid down the first tracks the very next day. Formed in in a small town in Switzerland, The Monsters are one of most trashy bands to have risen from that mountainous country. This makes The Monsters an unbelievably energetic live band, one that just kicks in and flips open to cut you like a Swiss army knife. The Parrots is a fresh-from-college young garage-surf trio from Madrid, set to cause a commotion in the garage-surf-punk scene this year.

Movie Star Junkies started as an Italian drum-and-organ blues duo. They tested their new line-up during a monthlong tour through Europe, playing in clubs, squats, galleries and streets. They like to stir things up a little every now and then, by adding a saxophone player for some free-jazz influences during their earlier tours for example.

Thee Oops With a collection of songs ranging from just over 40 seconds to just under a minute and a half, Thee Oops are certainly one of the fastest smashshit-up bands on the bill this year. But more likely it has something to do with sheer ironic fun and lots of beer.

Wreckless Eric With a career that spans 37 years, 17 albums and countless collaborations including Yo La Tengo, The Monkees and Die Toten Hosen, Wreckless Eric has been named one of the most important pop icons of the last forty years.

When punk finally arrived, Eric was instantly attracted to its DIY sense of freedom and became one of the earliest artists to be signed to Stiff Records. His wild drunken antics, both on stage and backstage, made him an eccentric figure with irresistible charm.

Yonathan Gat The story goes that Yonatan Gat former Tel Aviv based garage band Monotonix guitar virtuoso found the inspiration for his solo project while hearing Igor Domingues soundchecking at a festival in Portugal. Founded in , zZz is a Dutch duo from Amsterdam who make dark, danceable rock.

That might not sound very exciting, however their setup is what helps to create their remarkable sound: the band consists solely of an electric church organ and drums. Within a week after finding the organ they formed the band and made their first appearance playing at an underwater party. Their debut album was released in , followed by a two-year tour around the globe, during which zZz became known for their brutal and intense live performances and their massive sound.

Saturday November 22nd, the thriving neighbourhood around the Voorstraat will be transformed into a downtown festival. A substantial part of the Dutch underground and several international acts will be showcased at numerous venues, varying from record stores, clothing shops, art galleries to old cellars, small bars and lunch rooms.

In addition, cultmarket Le Bazarre returns on the Neude square and a new street will be introduced: the first shows of the day will take place at the Oosterkade. Treasure Guide. On November 22nd, the seventh edition of cult market Le Bazarre takes place at the Neude square. Wind your way through stalls of vintage, design, vinyl, books and graphic art; nose around for awesome second hand clothes and great regional products. Entrance to the market is free.

Expect a daily pop-up restaurant with fresh food, loads of snacks and goodness.. They enjoyed a decent cup of coffee every once in a while. A few years ago their dream became reality when they opened their own little place in de Voorstraat.

Why are they regulars at Le Guess Who? Because we also like great music and nice coffee! We also have some awesome Fuzzland merch in store for you, including t-shirts, sweater and Fuzzland guitarpedals! The bands explore the city and hang out in their free time between concerts. Over 45 national and international artists show recent work, established in cooperation with the depicted artist and pop venues.

A few artists made a special silkscreen print for acts performing at Le Guess Who? Most posters are for sale. A selection of photographs was published in Subbacultcha! Commissioned as independent photo shoots and shot mostly overseas, these are the results of unlikely encounters Subbacultcha!

Of all the shoots they have set up over the course of the year, these images have stuck with them the most. See you in ! We combine a top-notch collect See More. Program Guide 7 Warpaint Mascis Program Guide resourceful, and the boys of The Afterveins are no exception.

Baba Zula Baba Zula uses an outlandish mix of field recordings of natural sounds, traditional Turkish instrumentation and modern acoustic and electronic musical instruments and effects. Program Guide 11 Binkbeats Operating from what looks like a storage room filled with weird and out of time instruments, Binkbeats has become an unparalleled musical wizard, meticulously deconstructing electronic tracks and rebuilding them in a single live take.

Binkbeats 12 Le Guess Who? Program Guide Thematically Oldham shows he is a wellrounded musician who ages gracefully like fine bourbon, with some songs having an uplifting tone and absurd humour while others are suffocatingly dark. Their intensely dark psychedelic garage rock seems to effortlessly build to an inevitable climax, which they deliver with such energy that you can only stand baffled or join in on the madness.

Cut Hands William Bennett has always had a sweet spot for African sounds and rhythms. Daniel Norgren Swedish singer-songwriter Daniel Norgren used a set of home built instruments to record his debut album Kerosine Dreams, which gained him a loyal fan base of folky blues rock enthusiasts.

Program Guide If Flying Lotus brings you on tour as his keyboardist, you must be doing something right. Federico Albanese He rediscovered his love for the piano and started working on his own project, scoring documentaries and films with airy and cinematic piano pieces. Program Guide 23 Greylag The Greylag goose is a majestic animal. On some songs they gracefully take flight as they build it up from quiet to loud, while on others they deliberately keep it small and harmonious.

Point mutations were induced with about equal efficiency with each method, whereas crossing-over was induced preferentially when germinating conidia were exposed to MMS. On the other hand, non-disjunction was induced in germinating and quiescent spores with equal efficiency, but such segregants were not recovered with the selective fpa method.

The results are discussed for both their practical use in the mutagenic testing procedure and their theoretical implication. Induction of monooxygenation in rainbow trout by polybrominated biphenyls: a comparative study. Two commercial polychlorinated biphenyl mixtures Aroclor and Aroclor and one polybrominated biphenyl mixture FireMaster BP-6 were examined for their abilities to induce hepatic microsomal monooxygenation in rainbow trout Salmo gairdneri.

These enzyme activities remained elevated above control values for at least weeks. Arylhydrocarbon benzo[a]pyrene hydroxylation, ethoxycoumarin-O-deethylation and ethoxyresorufin-O-deethylation were increased by 6-, 3,- and fold, respectively. Only the latter two activities remained elevated two weeks post-injection.

Ethylmorphine-N-demethylation was unaffected by the polyhalogenated biphenyls. Significant increases in P hemoprotein were not observed after pretreatment with any of the polyhalogenated biphenyls studied. Effects of conventional vs high-dose rocuronium on the QTc interval during anesthesia induction and intubation in patients undergoing coronary artery surgery: a randomized, double-blind, parallel trial.

Myocardial ischemia, as well as the induction agents used in anesthesia, may cause corrected QT interval QTc prolongation. The objective of this randomized, double-blind trial was to determine the effects of high- vs conventional-dose bolus rocuronium on QTc duration and the incidence of dysrhythmias following anesthesia induction and intubation.

Fifty patients about to undergo coronary artery surgery were randomly allocated to receive conventional-dose 0. QTc, heart rate, and mean arterial pressure were recorded before induction T0 , after induction T1 , after rocuronium just before laryngoscopy; T2 , 2 min after intubation T3 , and 5 min after intubation T4. The occurrence of dysrhythmias was recorded. The QTc after high-dose rocuronium was not significantly longer than after conventional-dose rocuronium in patients about to undergo coronary artery surgery who were induced with etomidate and fentanyl.

In both groups, compared with baseline, QTc was most prolonged at 2 min after intubation, suggesting that QTc prolongation may be due to the nociceptive stimulus of intubation. Artificial intelligence-based speed control of DTC induction motor drives - A comparative study. Gadoue, S. The design of the speed controller greatly affects the performance of an electric drive. A common strategy to control an induction machine is to use direct torque control combined with a PI speed controller.

These schemes require proper and continuous tuning and therefore adaptive controllers are proposed to replace conventional PI controllers to improve the drive's performance. This paper presents a comparison between four different speed controller design strategies based on artificial intelligence techniques; two are based on tuning of conventional PI controllers, the third makes use of a fuzzy logic controller and the last is based on hybrid fuzzy sliding mode control theory.

To provide a numerical comparison between different controllers, a performance index based on speed error is assigned. All methods are applied to the direct torque control scheme and each control strategy has been tested for its robustness and disturbance rejection ability. Full Text Available Aim. This article is intended to develop a technique for monitoring the lining state of induction channel furnaces for melting oxygen-free copper by monitoring changes in the distribution of thermal fields in their lining and carrying out a comparative analysis of the developed technique with the existing one that controls the electrical resistance of the melting channel of the furnaces.

For carrying out the research, the theories of electromagnetic field, thermodynamics, mathematical physics, mathematical modeling based on the finite element method were used. A technique for diagnosing the lining state of the induction channel furnaces for melting oxygen-free copper has been developed, which makes it possible to determine the dislocation and the size of the liquid metal leaks by analyzing the temperature distribution over the body surface both the inductor and the furnace.

Scientific novelty. The connection between the temperature field distribution on the surface of the furnace body and the dislocation and dimensions of the liquid metal leaks in its lining is determined for the first time. Practical significance. Using the proposed technique will allow to conduct more accurate diagnostics of the lining conditions of the induction channel furnaces, as well as to determine the location and size of the liquid metal leaks, creating the basis for predicting the working life of the furnace.

Acute migraine therapy: recent evidence from randomized comparative trials. The incidence of labour induction has risen worldwide over the past decade, and this may contribute to the rising caesarean delivery rate. The mechanisms for induction of labour are generally divided into two categories: mechanical and pharmacological.

The objective of this study was to determine if mechanical induction with Dilapan-S is an acceptable, safe method of induction of labour in post-dates uncomplicated nulliparous pregnancy. This was a single-centre prospective observational pilot study trial. The primary outcomes measured were compliance to study protocol and maternal infection, hyperstimulation and neonatal outcomes Apgar score at birth.

The secondary outcome measures included change in Bishop's score and caesarean delivery rate. There were no differences in maternal and neonatal primary outcomes between the groups. There were no cases in either arm of hyperstimulation with either induction method. No difference between the groups was noted in the caesarean delivery rate nor in the mean change in Bishop's score.

Dilapan-S is an acceptable, safe form of induction of labour in post-dates uncomplicated nulliparous pregnancy. No cases of hyperstimulation were found, and therefore, Dilapan-S may be a suitable option for outpatient induction of labour in low-risk post-dates nulliparas. Effect of clomifene citrate plus metformin and clomifene citrate plus placebo on induction of ovulation in women with newly diagnosed polycystic ovary syndrome: randomised double blind clinical trial.

Moll, Etelka; Bossuyt, Patrick M. Comparative study of internal contamination of different radiators in skeleton on induction of mutagenic effect in bone marrow cells. The purpose of the present study was to ascertain comparative retention of Cs or Pm in skeleton on induction of chromosome aberrations and PCE's micronucleus formation in bone marrow cells. Results indicated that after iv signal nuclide Cs, through 7 weeks observation, the retention data in skeleton could be well described by an exponential expression.

Experiments indicated that the retention value and the absorption dose of Pm in skeleton were significantly higher in comparison with Cs. Both internal contamination of Cs or Pm could induce chromosome aberrations and PCE's micronucleus formation in bone marrow cells. Among the type of chromosome aberrations of bone marrow cells induced by Cs or Pm included gap, chromatid breakage, chromosome breakage and translocation.

Moreover, the chromosome aberration rates were elevated when the intake of radioactivity of Cs or Pm were enlarged. At the same time, chromosome fragment of bone marrow cells also induced by Cs or Pm only through high radioactive contamination. Studies showed that chromosome translocation was appeared only through high radioactivity of Pm contamination. By comparing with 1 '4 7 Pm, however, the induction of chromosome aberrations and PCE's micronucleus formation rates on bone marrow cells induced by Cs was quite low.

The mycotic ulcer treatment trial : a randomized trial comparing natamycin vs voriconazole. To compare topical natamycin vs voriconazole in the treatment of filamentous fungal keratitis. A total of patients were screened and were enrolled. Paediatric patients with acute myeloid leukaemia AML who fail induction due to primary resistance to chemotherapy account for a significant proportion of cases and have a particularly dismal prognosis.

These patients had a significantly higher white blood cell count at diagnosis compared to other AML patients. Cytogenetic and molecular features did not differ between patients with primary induction failure and patients allocated to the high-risk group. Intraoperative radiotherapy has been employed in human cancer research for over a decade. Since , trials to assess the acute and late toxicity of IORT have been carried out at the National Cancer Institute in an adult dog model in an attempt to establish dose tolerance guidelines for a variety of organs.

Of the animals entered on 12 studies with a minimum follow-up of 2 years, dogs received IORT; 22 control animals received only surgery. Animals were sacrificed at designated intervals following IORT, usually at 1, 6, 12, 24, and 60 month intervals. To date, 34 of the 46 animals have been sacrificed; the 12 remaining animals are to be followed to 5 years. These 12 animals have minimum follow-up of 30 months. In the irradiated group followed for greater than or equal to 24 months, 10 tumors have arisen in 9 animals.

One animal developed an incidental spontaneous breast carcinoma outside the IORT port, discovered only at scheduled post-mortem exam. The remaining nine tumors arose within IORT ports. Two tumors were benign neural tumors--a neuroma and a neurofibroma. One animal had a collision tumor comprised of grade I chondrosarcoma adjacent to grade III osteosarcoma arising in lumbar vertebrae.

An embryonal rhabdomyosarcoma sarcoma botryoides arose within the irradiated urinary bladder of one animal. No sham irradiated controls nor IORT animals sacrificed less than 24 months have developed any spontaneous or radiation-induced tumors. The time range of diagnoses of tumors was months. Tumor induction following intraoperative radiotherapy: Late results of the National Cancer Institute canine trials.

Barnes, M. Balancing the efficacy and safety of misoprostol: a meta-analysis comparing 25 versus 50 micrograms of intravaginal misoprostol for the induction of labour. The optimal dose of misoprostol for the induction of labour remains uncertain. To compare the efficacy and safety of 25 versus 50 micrograms of intravaginal misoprostol tablets for the induction of labour and cervical ripening.

We performed electronic and manual searches to identify relevant randomised trials. The efficacy outcomes assessed were rates of vaginal delivery within 24 hours, delivery within one dose, and oxytocin augmentation, and interval to delivery. The safety outcomes assessed were incidences of tachysystole, hyperstimulation, caesarean delivery, cesarean delivery for non-reassuring fetal heart rate FHR , operative vaginal delivery, abnormal 5-minute Apgar score, abnormal cord gas values, admission to a neonatal intensive care unit NICU , and meconium passage.

Thirteen studies women were included. We found that 25 micrograms was less efficacious, with lower rates of delivery after one dose RR 0. We noted an improved safety profile with 25 micrograms, however, with decreased rates of tachysystole RR 0. Although 50 micrograms of intravaginal misoprostol may be more efficacious, safety concerns make the microgram dose preferable.

Preoperative skin antisepsis has the potential to decrease the risk of surgical-site infection. However, evidence is limited to guide the choice of antiseptic agent at cesarean delivery, which is the most common major surgical procedure among women in the United States. In this single-center, randomized, controlled trial , we evaluated whether the use of chlorhexidine-alcohol for preoperative skin antisepsis was superior to the use of iodine-alcohol for the prevention of surgical-site infection after cesarean delivery.

We randomly assigned patients undergoing cesarean delivery to skin preparation with either chlorhexidine-alcohol or iodine-alcohol. The primary outcome was superficial or deep surgical-site infection within 30 days after cesarean delivery, on the basis of definitions from the Centers for Disease Control and Prevention. From September through June , a total of patients were enrolled; patients were assigned to chlorhexidine-alcohol and to iodine-alcohol.

In an intention-to-treat analysis, surgical-site infection was diagnosed in 23 patients 4. The rate of superficial surgical-site infection was 3. The frequency of adverse skin reactions was similar in the two groups.

The use of chlorhexidine-alcohol for preoperative skin antisepsis resulted in a significantly lower risk of surgical-site infection after cesarean delivery than did the use of iodine-alcohol. Louis; Clinical Trials. Hypnosis for induction of labour. Induction of labour using pharmacological and mechanical methods can increase complications. Complementary and alternative medicine methods including hypnosis may have the potential to provide a safe alternative option for the induction of labour.

However, the effectiveness of hypnosis for inducing labour has not yet been fully evaluated. To assess the effect of hypnosis for induction of labour compared with no intervention or any other interventions. We searched the Cochrane Pregnancy and Childbirth Group's Trials Register 31 January , handsearched relevant conference proceedings, contacted key personnel and organisations in the field for published and unpublished references.

All published and unpublished randomised controlled trials RCTs and cluster-RCTs of acceptable quality comparing hypnosis with no intervention or any other interventions, in which the primary outcome is to assess whether labour was induced. Two review authors assessed the one trial report that was identified but was subsequently excluded. There was no evidence available from RCTs to assess the effect of hypnosis for induction of labour.

Evidence from RCTs is required to evaluate the effectiveness and safety of this intervention for labour induction. As hypnosis may delay standard care in case standard care is withheld during hypnosis , its use in induction of labour should be considered on a case-by-case basis. Future RCTs are required to examine the effectiveness and safety of hypnotic relaxation for induction of labour among pregnant women who have anxiety above a certain level.

The length and timing of the intervention, as well as the staff training required, should be taken into consideration. Moreover, the views and experiences of women and staff should also be included in future RCTs. High-dose rapid and standard induction chemotherapy for patients aged over 1 year with stage 4 neuroblastoma: a randomised trial. The current standard treatment for patients with high-risk neuroblastoma includes initial induction chemotherapy with a day interval between induction treatments.

We aimed to assess whether an intensive chemotherapy protocol that had a day interval between treatments would improve event-free survival EFS in patients aged 1 year or over with high-risk neuroblastoma. Between Oct 30, , and March 18, , patients with stage 4 neuroblastoma who had not received previous chemotherapy were enrolled from 29 centres in Europe. Both regimens used the same total cumulative doses of each drug except vincristine , but the dose intensity of the rapid regimen was 1.

The standard regimen was given every 21 days if patients showed haematological recovery, whereas the rapid regimen was given every 10 days irrespective of haematological recovery. Primary endpoints were 3-year, 5-year, and year EFS. Data were analysed by intention to treat. Comparing of four IRT models when analyzing two tests for inductive reasoning.

This article discusses the use of the nonparametric IRT Mokken models of monotone homogeneity and double monotonicity and the parametric Rasch and Verhelst models for the analysis of binary test data. First, the four IRT models are discussed and compared at the theoretical level, and for each model,. Three phase Pulse Width Modulation inverter plays vital role in industrial applications.

The performance of inverter demeans as several types of faults take place in it. The IGBTs faults are broadly classified as base or collector open circuit fault, misfiring fault and short circuit fault. To develop consistency and performance of inverter, knowledge of fault mode is extremely important. This paper presents the comparative study of IGBTs fault diagnosis. Experimental set up is implemented for data acquisition under various faulty and healthy conditions. Recent methods are executed using MATLAB-Simulink and compared using key parameters like average accuracy, fault detection time, implementation efforts, threshold dependency, and detection parameter, resistivity against noise and load dependency.

Seventy patients with locally advanced nasopharyngeal carcinoma were treated in our department at their first visit from April to December They were divided randomly into two groups: the chronochemotherapy group 38 patients and conventional chemotherapy group 32 patients. In this procedure, prescribing the conventional intravenous infusion, intensity modulated radiation therapy was used after the induction chemotherapy. The prescribed nasopharyngeal lesion dose GTVnx was Sixty-six patients were evaluable for the response assessment.

There were 36 patients in the chronochemotherapy group and 30 patients in the conventional chemotherapy group. After the induction chemotherapy, no CR case was found in. Clinical trial to compare tinnitus masking and tinnitus retraining therapy. Both tinnitus masking TM and tinnitus retraining therapy TRT can be effective therapies for amelioration of tinnitus. TM may be more effective for patients in the short term, but with continued treatment TRT may produce the greatest effects.

Although TM and TRT have been used for many years, research has not documented definitively the efficacy of these methods. The present study was a controlled clinical trial to prospectively evaluate the clinical efficacy of these two methods for US military veterans with severe tinnitus.

Over veterans were screened to ensure that enrolled patients had tinnitus of sufficient severity to justify 18 months of individualized treatment. Treatment was administered at 0, 3, 6, 12, and 18 months. Outcomes of treatment were evaluated primarily using three self-administered tinnitus questionnaires Tinnitus Handicap Inventory, Tinnitus Handicap Questionnaire, Tinnitus Severity Index.

Findings are presented from the three written questionnaires with respect to three categories of patients: describing tinnitus as a 'moderate,' 'big,' and 'very big' problem at baseline. Based on effect sizes, both groups showed considerable improvement overall. For the patients with a 'moderate' and 'big' problem, TM provided the greatest benefit at 3 and 6 months; benefit to these TRT patients was slightly greater at 12 months, and much greater at 18 months.

For patients with a 'very big' problem, TM provided the greatest benefit at 3 months. For these latter patients, results were about the same between groups at 6 months, and improvement for TRT was much greater at 12 months, with further gains at 18 months. It is known that harmonics are generated in any power electronics based application.

Since presence of harmonics is not desirable, it is necessary to remove the harmonics. The IFOC is based on stator current regulation, and the stator currents are sensed and used in the speed control algorithm. The current needs to be free from noise and harmonics for accurate further processing. In this paper, a passive analog filter, as well as a 50th order FIR filter is designed in MATLAB and implemented in Code Composer Studio to remove noise and distortion, and a comparative analysis has been done, for the speed control of an induction motor fed through ZSI, for electric vehicle application.

A randomised controlled trial comparing the effect of adjuvant Background: Intrathecal adjuvants are added to local anaesthetics to improve the quality of neuraxial blockade and prolong the duration of analgesia during spinal anaesthesia. Used intrathecally, fentanyl improves the quality of spinal blockade as compared to plain bupivacaine and confers a short duration of post Clinical trial comparing excision and primary closure with modified Dec 3, Limberg flap, modified Limberg flap, gluteus maximus myo- cutaneous flap.

However, there have been few clinical studies to compare the rhomboid fasciocutaneous transposition flap The aim of this study was to compare modified Limberg flap procedure with excision and primary closure in the treatment of uncomplicated pilonidal disease.

Methods: This study was conducted on patients with uncomplicated sacrococcygeal pilonidal disease that were randomly allocated into two groups: group I Conclusions: This study showed that mg intramuscular paracetamol provides similar and modest pain relief in labor when compared to mg intramuscular tramadol. It also has fewer maternal adverse effects and favorable neonatal outcome such as tramadol. It is concluded that intramuscular paracetamol is simple, The recent rush of enthusiasm for public investment in comparative effectiveness research CER in the United States has focused attention on these public investments.

In this work, based on a simple revenue maximizing economic framework, we generate predictions on thresholds to invest in CER for a private manufactur The efficacy of maggot debridement therapy - a review of comparative clinical trials. However, comparative clinical trials and in particular randomized controlled trials investigating the efficacy of MDT are sparse.

A systematic search in the literature showed three randomized clinical trials and five non randomized studies evaluating the efficacy of sterile Lucilia However, the design of the studies was suboptimal, with important differences in the use of other therapies, such as compression, that may influence both debridement and healing between the compared groups, as well as inappropriately short follow Haemodynamic changes and intubating conditions during tracheal intubation in children under anaesthesia: a comparative study of two induction regiments.

Full Text Available Aim To compare the haemodynamic changes and intubation conditionsfollowing induction of anaesthesia with alfentanil-propofol-rocuronium with those following alfentanil-propofol combinationin children. Methods A prospective, non-randomized and non blinded trialwas performed in children ASA I-II, both gender, aged years undergoing elective adenoidectomy with or without tonsillectomy. Children scheduled for tonsillectomy or adenotonsillectomyreceived alfentanil 0.

Children scheduled for adenoidectomy received alfentanil 0. Haemodynamicvalues heart rate, systolic arterial pressure, diastolicarterial pressure, mean arterial pressure were recorded at predeterminedtime intervals before surgical incision.

The intubatingconditions were evaluated applying the Copenhagen Scoring System excellent, good, poor. Results There was no statistical difference in haemodynamicbaseline values, neither prior nor after the intubation betweenthe two groups.

There was a statistically significant increase inheart rate, systolic and diastolic arterial pressure after intubationin both groups p induction regiments provided the clinically acceptablehaemodynamics and intubation conditions during trachealintubation in children. We present an active full-wave rectifier with offset-controlled high speed comparators in standard CMOS that provides high power conversion efficiency PCE in high frequency HF range for inductively powered devices.

This rectifier provides much lower dropout voltage and far better PCE compared to the passive on-chip or off-chip rectifiers. The built-in offset-control functions in the comparators compensate for both turn-on and turn-off delays in the main rectifying switches, thus maximizing the forward current delivered to the load and minimizing the back current to improve the PCE. We have fabricated this active rectifier in a 0.

With 3. In addition, overvoltage protection OVP as safety measure and built-in back telemetry capabilities have been incorporated in our design using detuning and load shift keying LSK techniques, respectively, and tested. To examine whether labor compared with planned cesarean delivery is associated with increased maternal and neonatal morbidity. We conducted a retrospective cohort study of all women with body mass indexes BMIs at delivery of 50 or greater delivering a live fetus at 34 weeks of gestation of greater between January 1, , and December 31, Pregnancies with multiple gestations and major fetal anomalies were excluded.

Multivariate logistic regression adjusted for potential confounders. Women who labored were younger, more likely to be nulliparous, and less likely to have pre-existing diabetes. Composite maternal and neonatal morbidity was reduced among women who labored even after adjusting for age, parity, pre-existing diabetes, and prior cesarean delivery adjusted odds ratio 0. Despite high rates of cesarean delivery in women with superobesity, labor is associated with lower composite maternal and neonatal morbidity.

Severe maternal morbidity may be higher in women who require a cesarean delivery after labor. Haemodynamic stability during anaesthesia induction with propofol — impact of phenylephrine. A double-blind, randomised clinical trial.

We studied the efects of a parallel phenylephrine infusion during bispectral index guided anaesthesia induction with propofol on haemodynamic parameters. We hypothesised that mean arterial pressure and cardiac index would be better maintained in the group of patients receiving the phenylephrine infusion during induction.

Forty patients randomly received either a Full Text Available Myocardial ischemia, as well as the induction agents used in anesthesia, may cause corrected QT interval QTc prolongation. QTc, heart rate, and mean arterial pressure were recorded before induction T0, after induction T1, after rocuronium just before laryngoscopy; T2, 2 min after intubation T3, and 5 min after intubation T4. The decision to conduct a head-to-head comparative trial : a game-theoretic analysis.

Recent Medicare legislation calls on the Agency for Healthcare Research and Quality to conduct research related to the comparative effectiveness of health care items and services, including prescription drugs. This reinforces earlier calls for head-to-head comparative trials of clinically relevant treatment alternatives.

Using a game-theoretic model, the authors explore the decision of pharmaceutical companies to conduct such trials. The model suggests that an important factor affecting this decision is the potential loss in market share and profits following a result of inferiority or comparability.

This hidden cost is higher for the market leader than the market follower, making it less likely that the leader will choose to conduct a trial. The model also suggests that in a full-information environment, it will never be the case that both firms choose to conduct such a trial. Furthermore, if market shares and the probability of proving superiority are similar for both firms, it is quite possible that neither firm will choose to conduct a trial.

Finally, the results indicate that incentives that offset the direct cost of a trial can prevent a no- trial equilibrium, even when both firms face the possibility of an inferior outcome. This present study sought to review the feasibility and patients' satisfaction of laparoscopic cholecystectomy to be perform as daycare procedure. Sixty-two patients with symptomatic gallstones were recruited within a year.

They were randomized into overnight stay and daycare groups. The outcomes and post-operative complications were analyzed. Fifty-eight patients were eligible for analysis and four patients were excluded because of conversion to open cholecystectomy. Daycare laparoscopic cholecystectomy is safe and feasible.

The satisfaction of daycare surgery is higher than overnight stay group. Patients' selection is an important aspect of its success. Impact of parental presence during induction of anesthesia on anxiety level among pediatric patients and their parents: a randomized clinical trial. Stressful anesthesia induction has psychological adverse effects that recur with repeated anesthesia, can lead to increased pediatric discomfort during the recovery period, and may even induce reactionary postoperative behavior.

A randomized controlled trial was performed to assess the impact of parental presence during induction of anesthesia PPIA on preoperative anxiety of pediatric patients and their parents at three different times, cooperation of child with anesthesiologist at induction of anesthesia, and parental satisfaction. Patients and methods: A total of 96 pediatric patients undergoing elective minor surgery ASA 1—2 were randomly divided into two groups.

Both groups received oral midazolam 0. Purpose: Recent clinical trials and meta-analyses have shown that both CHART continuous hyperfractionated accelerated radiation therapy and induction chemotherapy offer a survival advantage over conventional radical radiotherapy for patients with inoperable non-small cell-lung cancer NSCLC. Results: Forty-six patients were randomized 23 in each treatment arm from 9 UK centers.

As a result of poor accrual, the trial was closed in December Twenty-eight patients were male, 28 had squamous cell histology, 34 were Stage IIIA or IIIB, and all baseline characteristics were well balanced between the two treatment arms. Phase III randomized trial of induction chemotherapy in patients with N2 or N3 locally advanced head and neck cancer.

The primary end point was overall survival OS. A total of patients were randomly assigned. With a minimum follow-up of 30 months, there were no statistically significant differences in OS hazard ratio, 0. However, the study was underpowered because it did not meet the planned accrual target, and OS was higher than predicted in both arms. Cohen, Ezra E. Results A total of patients were randomly assigned.

Comparative sulfur analysis using thermal combustion or inductively coupled plasma methodology and mineral composition of common livestock feedstuffs. The objective of this study was to compare the use of thermal combustion CNS and inductively coupled plasma ICP to measure the total S content in plant-, animal-, and mineral-based feedstuffs, and to provide concentrations of other macro- and micro-minerals contained in these feedstuffs. Forty-five feedstuffs total samples were obtained from suppliers as well as swine feed and pet food manufacturers throughout the United States.

In addition to total S, mineral composition data are provided for all feedstuffs as obtained by ICP analysis. Within specific feedstuffs, mineral composition was quite variable, potentially due to low concentrations in the feed-stuff causing high mathematical variation or due to the source of feedstock obtained. In general, analyzed values of P were similar to previous tabular values.

These data provide feed formulators a database from which modifications in dietary minerals can be accomplished and from which mineral requirements can be met more precisely to reduce losses of minerals into the environment. Inductively and capacitively coupled plasmas at interface: A comparative study towards highly efficient amorphous-crystalline Si solar cells. The interfaces were fabricated and processed by hydrogen plasma treatment using the conventional plasma-enhanced chemical vacuum deposition PECVD and inductively coupled plasma chemical vapour deposition ICP-CVD methods The influence of processing temperature, radio-frequency power, treatment duration and other parameters on interface properties and degree of surface passivation were studied.

In addition to the improvement of carrier lifetimes at low temperatures, low RF powers and short processing times, both techniques are efficient in band gap adjustment at sophisticated interfaces. Comparative retention of fission fragment Pm in regenerated and fetal liver on induction of chromosome aberrations in these cells.

The purpose of the present study is to ascertain comparative retention of fission fragment Pm in regenerated and fetal liver on induction of chromosome aberrations in these cells. The results indicated that retention of Pm in regenerated liver was about times than in fetal liver. The cumulative absorption dose in regenerated liver was about 2.

Under the same conditions, the incidence rate of chromosome aberrations in regenerated liver cells induced by Pm was It should be concluded that the radiosensitivity to Pm was not uniform among the regenerated and fetal liver cells. The study suggested that fetal liver cells show to be more radiosensitive to Pm than regenerated liver cells.

Among the type of aberrations in both cells induced by Pm, chromatid breakages were predominant, accompanied with a few chromosome breakages. Obesity and excess weight are significant clinical and public health issues that disproportionately affect African Americans because of physical inactivity and unhealthy eating. We compared the effects of alternate behavioral interventions on obesity-related health behaviors. We conducted a comparative effectiveness education trial in a….

An international randomized trial comparing four thrombolytic strategies for acute myocardial infarction. Simoons Maarten ; E. Topol Eric ; R. Califf Robert ; F. Armstrong Paul ; P. Aylward Philip Edmund ; G. Barbash; E.

Bates Eric ; A. Betriu; J. Chesebro James ; J. Col Jacques ; D. Gore Joel ; A. Guerci Alan ; J. Hampton John. The current trial was designed to compare new, aggressive. Comparative effectiveness of Tai Chi versus physical therapy for knee osteoarthritis: a randomized trial. Background: Few remedies effectively treat long-term pain and disability from knee osteoarthritis.

Studies suggest that Tai Chi alleviates symptoms, but no trials have directly compared Tai Chi with standard therapies for osteoarthritis. Objective: To compare Tai Chi with standard physical therapy f Comparison of the hemodynamic response to induction and intubation during a target-controlled infusion of propofol with 2 different pharmacokinetic models.

A prospective ramdomized trial. Determine the best propofol pharmacokinetic model that meets patient requirements and is devoid of major haemodynamic side effects. Prospective, randomised, open-label, clinical trial was performed on an intention to treat basis.

It included patients with ASA physical status i-iii, aged 18 to 80 years and weight range between 45 to kg, scheduled for surgery under general anaesthesia. They were randomized into 2 groups according to the pharmacokinetic model: Modified Marsh group and Schnider group.

The haemodynamic changes that occurred during the induction and intubation were analysed. A propofol target controlled infusion was started to achieve and maintain a bispectral index value between 35 and At minute 6, orotracheal intubation was performed and the study finished at minute Propofol doses and calculated concentrations and any hypotensive events were also recorded.

No differences were found between groups regarding haemodynamic performance. Schnider group The study failed to demonstrate any haemodynamic difference between the 2 groups, even though the Modified Marsh group received a larger dose of propofol. Vaccination using "naked" DNA is a highly attractive strategy for induction of pathogen-specific immune responses; however, it has been only weakly immunogenic in humans.

Also, in vivo electroporation was shown to enhance immune responses induced by conventional DNA vaccines. The vaccines used in this study encode the multiclade HIV-1 T cell immunogen HIVconsv, which is currently being evaluated in clinical trials. Using intradermal delivery followed by electroporation, the DREP. Responses induced by both DREP. HIVconsv and pTH. Using the same HIVconsv vaccines, the mouse observations were supported by an at least fold-lower dose of DNA vaccine in rhesus macaques.

These data point toward a strategy for overcoming the low immunogenicity of DNA vaccines in humans and strongly support further development of the DREP vaccine platform for clinical evaluation. Comparative study of 1,2-dimethylhydrazine and azoxymethane on the induction of colorectal cancer in rats. Full Text Available The induced colorectal carcinogenesis in rodents has a long history and currently uses the substances 1,2-dimethylhydrazine and azoxymethane.

Objective: The aim of this study was to compare the inductive effect of the substances azoxymethane and 1,2-dimethylhydrazine in colorectal carcinogenesis. Method: 30 randomly chosen male Wistar rats were divided into four groups. G1 group was treated with 1,2-dimethylhydrazine and C1 was its control group; G2 group was treated azoxymethane and C2 was its control group. The animals were weekly weighed until euthanasia, when their intestines were removed, processed and analyzed by an experienced pathologist.

Results: Among the control groups C1 and C2 no histologic changes were observed; moderate dysplasia was detected in G2 group; hyperplasia, mild dysplasia, severe dysplasia and carcinoma were observed in G1 group. When this study compared the cost of the substances, 1,2-dimethylhydrazine was more than 50 times less expensive than azoxymethane.

Conclusion: Azoxymethane is able to promote histological changes consistent with colorectal carcinogenesis. Usually, the environmental qualification test is carried out by the cable manufacturer and the test report is presented while the cable manufacturer supplies the tested cables in nuclear power plant.

If a cable manufacturer has environmentally qualified a cable for nuclear power plant more than a decade ago and the composition of the cable material is same, is it acceptable to use the old EQ report for recently manufactured cable?

Even though the manufacturer insists the composition of the tested cable and recently manufactured cable's material are same, there can some questions or opposing opinions for two cables, tested cable and recently manufactured cable's equality. In this case, how can I determine the equality for the two cables? It is well known method to use FT-IR to determine the similarity of cable materials.

FT-IR is easy tool to compare compositions of each material. But FT-IR method is not proper to compare aging trend of these materials. Oxidation induction time OIT testing is a technique that can be used to evaluate aging of organic materials and life assessment technique for cables used in nuclear power plants. In this paper, I studied the OIT technique to compare aging trend for the tested cable and recently manufactured cable to determine the equality for the two cables.

To study a equality analysis for cable materials, OIT measurement tests were performed for two cable insulation produced in and produced in which were supplied from same manufacturer. The two cables were irradiated up to 40 Mrad to simulate normal 40 years and thermally aged for hours at C equals to 40 years qualified life at The OIT measurement were made in order to compare aging trends of the '95 cable and the '13 cable, the test were performed for three sequential steps; initial, after Normal Radiation and after Thermal Aging.

The OIT measurement results at the temperature of C showed very similar degradation. Background: The ripeness of the cervix is an important determinant of the success of induction of labour. One of the mechanical methods of cervical ripening is the use of a transcervical Foley catheter. In this study we compared the efficacy in induction of labour of two insufflation volumes of Foley catheter bulb 30 mL and 60mL. A prospective randomized controlled multicenter trial comparing antibiotic therapy with appendectomy in the treatment of uncomplicated acute appendicitis APPAC trial.

Although the standard treatment of acute appendicitis AA consists of an early appendectomy, there has recently been both an interest and an increase in the use of antibiotic therapy as the primary treatment for uncomplicated AA. However, the use of antibiotic therapy in the treatment of uncomplicated AA is still controversial. The APPAC trial is a randomized prospective controlled, open label, non-inferiority multicenter trial designed to compare antibiotic therapy ertapenem with emergency appendectomy in the treatment of uncomplicated AA.

The primary endpoint of the study is the success of the randomized treatment. In the antibiotic treatment arm successful treatment is defined as being discharged from the hospital without the need for surgical intervention and no recurrent appendicitis during a minimum follow-up of one-year treatment efficacy.

Secondary endpoints are post-intervention complications, overall morbidity and mortality, the length of hospital stay and sick leave, treatment costs and pain scores VAS, visual analoque scale. A maximum of adult patients aged years with a CT scan confirmed uncomplicated AA will be enrolled from six hospitals and randomized by a closed envelope method in a ratio either to undergo emergency appendectomy or to receive ertapenem 1 g per day for three days continued by oral levofloxacin mg per day plus metronidazole 1.

Follow-up by a telephone interview will be at 1 week, 2 months and 1, 3, 5 and 10 years; the primary and secondary endpoints of the trial will be evaluated at each time point. Economic evaluation of the randomized European Achalasia trial comparing pneumodilation with Laparoscopic Heller myotomy.

Moonen, A. BackgroundA recent multicenter randomized trial in achalasia patients has shown that pneumatic dilation resulted in equivalent relief of symptoms compared to laparoscopic Heller myotomy. Additionally, the cost of each treatment should be also taken in consideration.

Therefore, the aim of the present. Comparing surgical repair with conservative treatment for degenerative rotator cuff tears : a randomized controlled trial. Background: Good clinical results have been reported for both surgical and conservative treatment of rotator cuff tears.

The primary aim of this randomized controlled trial was to compare functional and radiologic improvement after surgical and conservative treatment of degenerative rotator cuff. Objectives: To determine the effect of pituitary suppression with a GnRH agonist GnRH-a on the success of ovulation induction with exogenous gonadotropins in patients with premature ovarian failure POF.

Design: Placebo-controlled, randomized, double-blind study. The data were analyzed with a. Plasma exchange for induction and cyclosporine A for maintenance of remission in Wegener's granulomatosis--a clinical randomized controlled trial. We conducted two randomised, double-blind,. Maintenance based Bevacizumab versus complete stop or continuous therapy after induction therapy in first line treatment of stage IV colorectal cancer: A meta-analysis of randomized clinical trials.

In stage IV colorectal cancer, bevacizumab-based maintenance therapy, complete stop therapy and continuous therapy are considered all possible approaches after first line induction chemotherapy. However, there are no clear data about which approach is preferable.

All randomized phase III trials comparing bevacizumab-based maintenance therapy MB with complete stop therapy ST or with continuous therapy CT were considered eligible and included into the analysis. Primary endpoint was the Time to failure strategies TFS. Although without observing any statistically advantage, it should be highlighted that MB versus ST showed a trend in favour of MB. We observed no difference between MB and CT. MB should be considered the standard regimen in patients with stage IV colorectal cancer after first line induction therapy.

Albendazole versus praziquantel in the treatment of neurocysticercosis: a meta-analysis of comparative trials. We investigated the role of albendazole and praziquantel in the treatment of patients with parenchymal neurocysticercosis by performing a meta-analysis of comparative trials of their effectiveness and safety. Six studies were included in the meta-analysis. There was no difference between albendazole and praziquantel in reduction of cysts, proportion of patients with adverse events, and development of intracranial hypertension due to the administered therapy.

Nevertheless, given the relative scarcity of trials , more comparative interventional studies--especially randomized controlled trials --are required to draw a safe conclusion about the best regimen for the treatment of patients with parenchymal neurocysticercosis.

Bevacizumab avastin and erlotinib tarceva had shown early clinical activity against head and neck cancer HNC. The goal was to determine maximum tolerated erlotinib dose. Two cycles of induction TPF-E were administered. XRT was administered with concurrent weekly cisplatin and bevacizumab every 2 weeks.

Initial erlotinib dose was 50 mg daily from start of induction chemotherapy until radiotherapy completion. Erlotinib dose escalations to and mg were planned. Thirteen patients with previously untreated locoregional disease 11 patients or oligometastatic 2 patients HNC were enrolled. Totally, 11 of 13 patients completed XRT as planned. Four of 8 patients in cohort 1 erlotinib 50 mg , 3 of 4 patients in cohort 2 mg , and 0 of 1 patients in cohort 3 mg completed the regimen. Two patients had significant gastrointestinal complications bleeding and perforation , and 1 had dose-limiting diarrhea.

Maximum tolerated dose was reached at 50 mg erlotinib. At median Erlotinib in combination with induction TPF followed by erlotinib, cisplatin, and bevacizumab with XRT is active but toxic. Gastrointestinal toxicities partly caused high rates of study withdrawal.

All doses studied in this protocol caused unexpected toxicities and we do not recommend advancement to phase II. Rosmarinus officinalis L. After a baseline visit, patients returned to the clinic for efficacy and safety evaluations every 3 months. A standardized professional microphotographic assessment of each volunteer was taken at the initial interview and after 3 and 6 months of the trial.

In contrast, both groups experienced a significant increase in hair count at the 6-month endpoint compared with the baseline and 3-month endpoint P. The frequency of scalp itching at the 3- and 6-month trial points was significantly higher compared with baseline in both groups P minoxidil group at both assessed endpoints P trial provided evidence with respect to the efficacy of rosemary oil in the treatment of AGA.

Results of a prospective randomised trial comparing conventional radiotherapy to split course bifractionated radiation therapy in patients with nasopharyngeal carcinoma. Background and purpose: Nasopharyngeal carcinoma NPC is generally responsive to radiation therapy. However therapeutic results after conventional radiotherapy remain relatively poor especially for patients with locoregional advanced NPC. The aim of this study was to evaluate the impact of a split course bifractionated radiotherapy regimen in a phase III randomised trial.

Patients and methods: From January to September , patients with M0 histologically proven NPC were treated in our institution. Patients with locally advanced nodal disease N2-N3 received induction chemotherapy. Results: Patients were well balanced between the two arms. Comments: The present trial comparing conventional radiotherapy to a split course bifractionated radiation therapy failed to demonstrate significant improvement in locoregional control and survival in experimental arm which was associated with more grade II-III skin.

Incidence of fetal distress in 6 hourly vaginally administered 3 doses, of misoprostol versus dinoprostone for labour induction : a comparative study. Background: Artificial labor pain always poses the risk of fetal distress and is more painful than spontaneous labour.

The pharmacological agents that are involved in stimulating uterine contraction may initiate a chain of processes that may lead the baby to suffocate, being deficient of essential oxygen and suffer from distress. The accelerated efforts to adapt safe and advanced measures are inevitable to make the labour induction easier and more secure for both lives involved. Objective: The objective of this study was to compare the incidence of fetal distress in 6 hourly vaginally administered 3 doses, of misoprostol versus dinoprostone for labour induction.

A total of postdate primigravidas undergoing induction of labour at 41 weeks were selected for this study. They were randomly divided into misoprostol and dinoprostone group, each containing patients. The dose of misoprostol was 50 microgram each time up to a maximum of microgram 3 doses and dose of dinoprostone was 2 mg and only 2 doses of dinoprostone were used with an interval of 6 hours. Continuous fetal heart rate monitoring was done after induction. Signs of fetal distress like meconium staining of liquor after rupture of membranes and CTG changes were noted.

After delivery of baby Apgar score at 5 minutes was taken and any resuscitation required or need for keeping the baby in nursery was noted. Results: The mean age of the patients in misoprostol group was The mean duration of induction to delivery interval in misoprostol group was A comparative analysis of quality management standards for contract research organisations in clinical trials. This article compares and contrasts the main quality standards in the highly regulated pharmaceutical industry with specific focus on Good Clinical Practice GCP , the standard for designing, conducting, recording and reporting clinical trials involving human participants.

Comparison is made to ISO quality standards, which can be applied to all industries and types of organisation. The study is then narrowed to that of contract research organisations CROs involved in the conduct of clinical trials. The paper concludes that the ISO series of quality standards can act as a company-wide framework for quality management within such organisations by helping to direct quality efforts on a long-term basis without any loss of compliance.

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